Pharmacogenomics: will the promise be fulfilled?

Vitamin D and cancer: the promise not yet fulfilled.

The negative association of the latitude where people live and the incidence of non cutaneous cancer in that population in North America have been demonstrated in many studies for many types of cancer. Since the intensity of UVB exposure decreases with increasing latitude, and UVB exposure provides the mechanism for vitamin D production in the skin, the hypothesis that increased vitamin D provi...

Circulating microRNAs as potential biomarkers of coronary artery disease: a promise to be fulfilled?

Atherosclerotic coronary artery disease (CAD) continues to be an important socioeconomic problem and the leading cause of death in the Western world. Several cellular components, including endothelial, inflammatory, and smooth muscle cells of the arterial wall, participate in the generation of an atherosclerotic plaque,1 the growth of which is responsible for a progressive narrowing of the lume...

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Diversity in Clinical and Biomedical Research: A Promise Yet to Be Fulfilled

Esteban Gonzalez Burchard and colleagues explore how making medical research more diverse would aid not only social justice but scientific quality and clinical effectiveness, too.

IVUS-Guided Stent Implantation to Improve Outcome: A Promise Waiting to be Fulfilled

The use of intravascular ultrasound (IVUS) to improve acute angiographic results was already shown in the prestent era. Various studies demonstrated the efficacy of IVUS in balloon sizing and estimating the extent of positive remodeling. With the introduction of drug-eluting stents (DES) the rate of restenosis has been significantly reduced but a new concern, the risk of stent thrombosis, has e...